Endocrine Abstracts

Background/objective: The prevalence of low serum TSH in the general population is in the order of 2.5–3.9%, and increases with age. True subclinical hyperthyroidism (SH) (low/suppressed serum TSH, normal serum fT4 and fT3) is less common. In one population based study of 1193 subjects, 66 (5.5%) were found to fit the criteria for SH. Of these, 75% had serum TSH 0.05–0.5 mIU/l, of whom 76% normalised within 12 months. At 12 months 87.5% subjects with serum TSH <0...

Acromegaly and hypogonadism represent independent cardiovascular risk factors, worsening either different metabolic parameters or quality of life (QoL).In our cohort of 41 acromegalic males (20–82 years), 35 resulted affected by hypogonadotropic hypogonadism, while only six were eugonadal. Twenty-nine out 35 had low testosterone levels at diagnosis and six developed a post-surgical hypogonadism (testosterone cut-off: 350 ng/dl). Among hypogonadal su...

Gastrointestinal abnormalities in acromegaly include dolichomegacolon and increased prevalence of colonic polyps. No data are available on the small intestine. The aims of this study were to investigate orocecal transit time (OCTT) and the presence of small intestinal bacterial overgrowth (SIBO) in acromegaly. 41 acromegalic patients and 30 controls entered the study. Acromegalics were classified according to whether they were on medical treatment with somatostatin analogs (SS...